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加拿大阿尔伯塔代写作业:镰状细胞病

Keywords:加拿大阿尔伯塔代写作业

镰状细胞病的影响70 000到80 000的美国人,非洲,Mediterranean和中东的继承(Mentzer和坎河,2006)。这种疾病的特点是红细胞变形,聚合在除氧、坚持与血管内皮细胞,导致血流量减少和血管阻塞。贫血、痛苦的事件,除了器官的损害,对于这些患者常见问题(聚类和Vichinsky,2003),(法塔拉赫和atweh,2006),(门策,坎河,2006)。Thalassaemia是最常见的单基因疾病,是众所周知的在Mediterranean、中东和亚洲的人出现,起源(Mentzer和坎河,2006)。疾病的严重程度因患者在调节区或实际的珠蛋白编码序列的不同突变而变化。障碍对杂合子携带者的影响不大,但是这是没有的情况下当继承地中海贫血是从两个载体的父母。在这种情况下,一个危及生命的贫血,需要输血的正常红细胞的结果,和其它并发症如铁超载发生(Mentzer和坎河,2006),β-地中海贫血、β-珠蛋白基因突变的影响,这导致减少或完全丧失的珠蛋白链合成。这导致不成对的,不溶性α链的积累。红血细胞被破坏,这导致过早无效erthropoiesis和溶血性贫 .
加拿大阿尔伯塔代写作业:镰状细胞病
Sickle cell disease affects 70 000 to 80 000 Americans of African, Mediterranean or Middle Eastern inheritance (Mentzer and Kan, 2006). The disorder is characterised by deformed red blood cells that polymerises upon deoxygenation, and adhere to vascular endothelium, resulting in reduced blood flow and vascular obstruction. Anaemia, pain events, in addition to organ damage, are common problems for these patients (Claster and Vichinsky, 2003), (Fathallah and Atweh, 2006), (Mentzer and Kan, 2006).Thalassaemia is the most common single gene disorder and is known to occur in people of Mediterranean, Middle Eastern, and Asian origin (Mentzer and Kan, 2006). The severity of the disease varies between patients due to different mutations in the regulatory regions or in the actual globin coding sequence. The disorder has little effect on heterozygous carriers, however this is not the case when inheritance of thalassaemia is from two carrier parents. In this case, a life threatening anaemia that requires transfusion of normal red blood cells results, and additional complications such as iron overloading occurs (Mentzer and Kan, 2006).For beta-thalassaemia, mutations affect the beta-globin gene, which results in a reduction or complete loss of synthesis of the globin chain. This results in an accumulation of unpaired, insoluble alpha-chains. Red blood cells are destroyed prematurely and this leads to ineffective erthropoiesis and haemolytic anaemia

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