Generalised anxiety disorder (GAD) is primarily characterised by fear whereas depression is characterised by prolonged sadness that affects the individuals lives. Generally, depression and anxiety are similar in terms of their main defining symptoms in terms of their mental symptoms such as thoughts and feelings as well as the fact that they are both caused by chemical changes in the brain due to low serotonin levels as well as a change in dopamine and epinephrine levels. However, they both have physical manifestations which may possess a number of differences between the two conditions. Depression is defined by two main symptoms which is having a low mood or a loss of interest in the individual’s normal day to day activities. A person with depression may also experience, hopelessness, low confidence and feeling worthless, indifference, prolonged sadness and thoughts of death or suicide, they have to experience five or more of these symptoms over a period two weeks in order to be diagnosed with depression. Similarly, GAD centres on two main symptoms as well, this can be associated with excessive anxiety and worry, and difficulty controlling these feelings of anxiety which may cause a more severe outcome. Other symptoms are associated with irritability, feeling restless and uneasy as well as prolonged sadness and in order to be diagnosed they have to experience these symptoms on most days in the period of six months or more. Also, both mental health disorders have similar physical symptoms such as fatigue or tiredness, low concentration, being fidgety or unable to stay still, headaches, slow responses and thinking and lastly difficulties sleeping. However, while having similar physical symptoms they also possess their own distinguishing symptoms, for example the physical effects of anxiety may include dizziness, sweating, bowel issues, hyperventilation, shaking and restlessness, whereas with depression the physical symptoms include slow movements, weight changes due to a drastic change in appetite, excessive sleeping, lack of energy or emotion as well as painful cramps. All of which can potentially be signs of a number of other issues regarding an individual’s physical health.