美国密歇根论文代写:基因进化
Keywords:美国密歇根论文代写
基因进化一直被认为是主要推动通过基因重复和重排机制自1970年以来s3。这项研究说明了一个新的驱动基因进化的力量:也就是说,正面碰撞DNA复制和转录。因此,它提出了一个问题是否有其他重要因素基因进化。小的规模,作者展示了积极的选择为面向正面基因的复制,而突破思维局限于co-oriented基因的进化选择。
另一方面,本文中的结论只适用于枯草芽孢杆菌,离开的问题,如果这甚至适用于其他原核生物和真核生物。以酵母为例,转录相关基因突变影响的研究取向的金等al.4;而碰撞影响DNA转录方向独立Azvolinsky et al.5的纸。这些矛盾的结果表明,系统研究的其他生物需要决定是否本文的结果可以扩展到其他的生物。
Gene evolution has been thought to be chiefly impelled by gene duplication and rearrangement mechanisms since 1970s3. This study illustrates a new driven force for gene evolution: that is, head-on collision between DNA replication and transcription. Thus, it raises a question whether there are other important factors driving gene evolution. At the small end of the scale, the authors show the positive selection for a gene that is head-on oriented with replication, which breaks through the thought limited to the evolutionary selection for co-oriented genes.
On the other hand, the conclusion reached in this paper is only applied to Bacillus subtilis, leaving question that if it holds true for other prokaryotes and even eukaryotes. Take yeast as an example, transcription associated mutation is influenced by the orientation in study of Kim et al.4; while the collisions negatively affect DNA transcription independent of orientation in paper of Azvolinsky et al.5. These contradictory results demonstrate that systematic studies of other organisms are needed to decide whether the results of this paper can extend to other organisms.
