Knowledge is one of the essential qualities of the nursing profession, it ensures patient safety while providing quality care. It is important to keep up-to-date with education and understanding that best practice care is vital to the nursing profession. The knowledge refers to the science of nursing, providing evidence and guidance in managing illnesses. Being educated in the nursing profession helps to understand care plans, follow-ups, medications, referrals, and types of equipment. A lack of sufficient education can lower a nurse’s confidence in applying scientific knowledge to practice. This could also influence the patient-client therapeutic relationship with uncertainty and self-doubt which can be dangerous in critical situations. Crowea suggested that nurses are expected to have the knowledge to swiftly and efficiently assess patient condition if this does not occur it leads to improper patient care and even deaths. Factors that influence the delay or absence of action are knowledge, communication, and confidence. Research recommendations and simulation education have significant impacts on nurses confidently identifying patient care (2017). Indicates that professional nurses are expected to have appropriate knowledge for safe, competent practice and uphold the professional standards. Due to the simulation education, nurses show increased performance in diagnostic recognition while obtaining more confidence and better therapeutic relationships (Crowea, 2017). Identifies the significance of knowledge in improving nursing performance and shows relevance to communication and confidence. Nursing is seen as a science and art field, science is represented in the form of a nurse’s knowledge, while the art is demonstrated in the form of empathy; this enables in a patient-centered practice.